I good type of prokaryote (which is bacteria) would be yeast. Yeast is a good fungi. It's not harmful at all. It is used for baking, and for making alcoholic beverages. The way it helps humans is that it provides food for us. So most likely it isn't harmful at all since they use it in food daily and in beverages too.
Now a harmful bacteria would be Streptococcus. It can cause infections like strep throat. Sometimes even a serious diseases like pneumonia. At times Streptococcus and be fatal.
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